Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, Eric Christensen.

Thanks so much for taking the time to listen today. Also remember, go check out real life

pharmacology.com. Hit our subscribe button for the top 200 drugs and get that 31 page PDF for free

of the top 200 drugs.

I discuss lay out the pharmacology in there,

as well as some of the most important things that you're going to actually see in clinical practice.

So, again, check that out at real-life pharmacology.com.

All right, so let's get into the drug today.

I'm going to talk about nortriptylene.

Brand name of this medication is Pamilor.

And I certainly do see this medication used periodically in clinical practice.

So first off, it is a tricyclic antidepressant.

I did a little bit of a general overview of TCA's before, but wanted to dig down deep with nortryptylene, because there's definitely some unique quirks with it that I wanted to point out.

So the diagnosis that we're most likely going to see with this medication, or at least the most common I've seen in clinical practice, is in association with various types of pain.

Technically, it's classified as an antidepressant. It can certainly be used for that. I've probably

seen it more so in nerve type pain personally. So, you know,

you think of diabetic neuropathy, post-depatic neuralgia, things like that. But it is off-label.

It isn't technically FDA approved for that, but we've got some evidence saying that it can be

beneficial potentially in

those specific diagnoses. Other kind of unique indications that I have seen, rarely I have seen

it used for chronic headaches. I have seen it used like second or third line down the road for smoking cessation

as well. So kind of a jack of all trades, drugs. And as I think about this medication, I recognize

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