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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Hyoscyamine Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 16 April 2020

⏱️ 12 minutes

🧾️ Download transcript

Summary

Hyoscyamine is an anticholinergic medication that is primarily used for GI problems like spasms and pain associated with IBS.



Because of the highly anticholinergic nature of hyoscyamine, it can cause dry eyes, dry mouth, urinary retention, and constipation.



Be aware of the risk for the prescribing cascade with hyoscyamine. Saliva substitutes for dry mouth, artificial tears for dry eyes, etc.



Sedation is a concern with hyoscyamine and this can be exacerbated by drugs like benzodiazepines, opioids, and older antihistamines.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, Eric Christensen.

0:05.7

And today, the medication I'm going to cover is hyocyanine. Now, this is a medication,

0:12.6

I will be frank with you and say that I don't see a terribly often amount. With that said, you're going to experience that in clinical practice where you come across

0:24.7

meds that, you know, you don't see terribly often, but you need to obviously be able to

0:30.8

dig into it, look, and make sure you know what that medication does, how that medication

0:36.6

works, and how that interplay

0:38.1

may play out with other medications.

0:40.5

So, hi-assignment, brand names of this medication, Levson and Anaspas are the two names I've

0:49.5

heard thrown around.

0:51.7

Anaspas, a good way to help remember the indication for this medication or where it's

1:01.2

primarily used, at least where I see it used in clinical practice, is think of antispasm,

1:07.6

anaspas, in that it can help patients with symptoms of GI spasms, GI pain, symptoms

1:18.5

mainly associated with IBS and things of that nature.

1:23.7

I've done dicyclamine in the past, so it's going to be kind of a similar mechanism,

1:31.1

similar adverse effect profile in general.

1:34.7

So mechanistically, it works similar to dicyclamine.

1:39.0

It is an anticholinergic medication that basically helps kind of ease that smooth muscle reduces that cramping

1:48.3

um but can slow down the GI tract as well which you know can have some negative aspects to

1:54.9

it as well so that relaxation of smooth muscle that provides kind of of that pain relief, that benefit potentially in G.

2:05.3

In addition, the anticholinergic effects, we can obviously have some troublesome problems from those effects.

2:15.8

So anticholinergics, dry eyes, dry mouth, urinary retention, constipation, confusion,

2:22.0

increasing fall risk, particularly in our geriatric patient population.

...

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